Where did Axl Rose get arthritis?

… in his sha-na-na-na-na-na-na-na-knees knees!

Sorry– had to *crack* a little arthritis joke. 🥴

Anyway…

When someone is suffering from arthritis, cartilage-destroying chemicals affect their joints. Catabolic proteases (chemicals that cause cartilage to break down) result in pain and inflammation. The disease will eventually cause the cartilage to degrade completely, resulting in painful friction of bones rubbing together. In healthy joints, cartilage works as a buffer to prevent bone-on-bone contact.⁣⁣

A2M halts the progression of osteoarthritis at the molecular level by inactivating the chemicals that cause cartilage breakdown. As the A2M captures and neutralizes the damaging chemicals, the body will work to eliminate them. The joint will then begin to recover, as the inflammation is subdued, and harmful chemicals are no longer present. A2M remaining in the joint will promote tissue growth and the joint can begin the restoration process. The repair will then lead to a pain-free joint.⁣⁣